Molaz — Molnupiravir 200 mg Capsules, 40 Caps

Molaz is manufactured in oral capsule form:

• Dosage Form and Packaging: 1 plastic bottle contains 40 capsules, packed in a protective cardboard box.
• Active Ingredient: Molnupiravir — 200 mg per capsule.
• Excipients: Pregelatinized starch, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, titanium dioxide, gelatin (capsule shell).

Pharmacodynamics: Molnupiravir is metabolized to the active ribonucleoside analogue N4-hydroxycytidine (NHC). Within infected cells, NHC is phosphorylated to NHC-TP and incorporated into viral RNA by RNA-dependent RNA polymerase, causing lethal mutagenesis (viral error catastrophe). This mechanism is effective against human RNA viruses as well as Feline Coronavirus (FCoV/FIPV).

Pharmacokinetics: Rapidly absorbed and converted to NHC in plasma. High oral bioavailability. Excreted mainly as metabolites via urine and feces.

Molaz is used in the following scenarios:

• 🔹 Human Medical Use: Treatment of mild-to-moderate COVID-19 in adult patients at risk of severe disease progression (initiated within the first 5 days of symptoms).
• 🔹 Veterinary Use (Off-label): Treatment of Feline Infectious Peritonitis (FIP) in cats (wet, dry, ocular, and neurological forms), as primary therapy or for relapses after GS-441524 treatment.

Administration guidelines for Molaz:

• 👤 For Humans: 800 mg (4 capsules of 200 mg) every 12 hours for 5 days. Swallow whole with water.
• 🐾 For Cats (Veterinary Protocol): Dosage is calculated strictly by the cat's body weight (typically 12.5 mg/kg to 15–20 mg/kg twice daily for standard FIP, up to 25–30 mg/kg for neurological FIP). Capsule contents are measured by a veterinary professional and mixed with wet food or treats. FIP treatment duration is typically 84 days (12 weeks) under veterinary monitoring.

Molaz is contraindicated in:

• ❌ Hypersensitivity to molnupiravir or excipients.
• ❌ Pregnancy and lactation (in humans and animals due to embryofetal toxicity).
• ❌ Patients under 18 years old (human use due to bone growth effects). In growing kittens, used with extreme caution under veterinary supervision for life-threatening FIP.

Consider the following drug interactions for Molaz:

• ⚠️ General Compatibility: Low potential for CYP enzyme interactions; safe to combine with most standard medications.
• ⚠️ Veterinary Context: Compatible with hepatoprotectants, antiemetics, and supportive care drugs under blood work monitoring.

Strictly contraindicated during pregnancy and lactation. Effective contraception is required during treatment and for 4 days post-treatment for females, and 3 months post-treatment for males. Do not use in pregnant or nursing animals.

Side effects of Molaz:

• 🤢 In Humans: Nausea, diarrhea, dizziness, headache, rash.
• 🐾 In Cats: Transient lethargy, nausea, vomiting, mild diarrhea, temporary elevation of liver enzymes (ALT/AST), rare blood count changes during prolonged use.

Symptoms: Severe gastrointestinal distress, lethargy, anorexia.

Treatment: No specific antidote. Perform gastric lavage if recent, administer adsorbents, and provide supportive veterinary care.

Storage rules for Molaz:

• 🌡️ Temperature: Store between 15 °C and 30 °C in the original container.
• 💧 Moisture: Keep bottle tightly closed. Store compounded/divided doses in dry, sealed containers.
• 👶 Safety: Keep out of reach of children and unauthorized animals.

Authenticity features of original Molaz:

• 🛡️ Packaging: Official Azista multi-colored flower logo. White and orange packaging with virus graphics.
• 🔍 Markings: Clearly printed Batch No., Mfg. Date, Exp. Date, and Mfg. Lic. No. on bottle and carton.
• 📦 Container: Sealed white plastic bottle with protective membrane containing exactly 40 capsules.