Sofoxen (Sofosbuvir) Tablets

Indicated for the treatment of chronic Hepatitis C (CHC) in adults:

• 🦠 Pan-genotypic: Used for genotypes 1, 2, 3, 4, 5, and 6.
• 🏥 Advanced Liver Disease: Effective in patients with cirrhosis (compensated and decompensated).
• 🛡️ Special Populations: Safe for patients co-infected with HIV and those awaiting liver transplantation.

Packaging: 400 mg film-coated tablets.

⚠️ ADMINISTRATION PROTOCOL:

• 💊 Dose: One tablet (400 mg) orally once daily.
• 🕒 Consistency: Take at the same time every day to prevent viral breakthrough.
• 🍲 Usage: May be taken with or without food. Swallow whole (do not chew or crush due to bitter taste).
• 📅 Duration: Typically 12 weeks. Extended to 24 weeks for difficult-to-treat patients.

• Monotherapy: Must be used in combination with other antiviral agents.
• ❤️ Drug Interaction: Co-administration with Amiodarone is contraindicated due to risk of severe symptomatic bradycardia.
• Pregnancy and breastfeeding.
• Use with potent P-gp inducers (e.g., Rifampin, St. John's Wort).

Sofosbuvir has a favorable safety profile. Common adverse events include:

• 💤 General: Fatigue, irritability.
• 🤯 Neurological: Headache, insomnia.
• 🤢 Gastrointestinal: Nausea.
• ⚠️ Note: Most side effects are mild and transient.