Arsenam 10 — Arsenic Trioxide 10 mg / 10 ml, 1 pcs, GLS

Arsenam 10 (Arsenic Trioxide) 10 mg/10 mL

1252₴ 1475₴ -15%
1
Active ingredient
Arsenic Trioxide
Manufacturer
GLS
Dosage
10 mg / 10 ml
Dosage form Concentrate for solution for infusion
Vials per pack 1

Arsenam 10 (Arsenic Trioxide 10 mg/10 ml) is a specialized antineoplastic agent.

Manufacturer: GLS Pharma (India). It is a generic version of Trisenox. Historically known as a poison, in modern oncology, it acts as a potent life-saving drug for specific leukemia types.

Mechanism of Action ("Targeted Apoptosis"):

Arsenic Trioxide induces partial differentiation and promotes apoptosis (programmed cell death) of leukemic cells. It specifically targets the PML-RARα fusion protein, which is the root cause of Acute Promyelocytic Leukemia, forcing cancer cells to mature and die naturally.

✅ Key Benefit: High remission rates in patients with relapsed or refractory APL.

Indicated specifically for:

  • 🩸 Acute Promyelocytic Leukemia (APL): Particularly for induction of remission and consolidation in patients who are refractory to, or have relapsed from, retinoid and anthracycline chemotherapy.
  • Characterized by the presence of the t(15;17) translocation.

Packaging: 10 ml Vial (Concentration 1 mg/ml).

⚠️ ADMINISTRATION & SAFETY:

  • 💉 IV Infusion: Must be administered intravenously over 1-2 hours. NEVER as a bolus push.
  • ⚡ ECG Monitoring: Arsenic can cause serious heart rhythm problems (QT prolongation). An ECG is mandatory before dosing.
  • 🧪 Electrolytes: Potassium and Magnesium levels must be maintained in the normal range to protect the heart.

  • Pregnancy and breastfeeding (embryo-fetal toxicity).
  • Hypersensitivity to arsenic.
  • Severe cardiac arrhythmias (specifically congenital long QT syndrome).

Critical side effects to watch for:

  • 🚨 APL Differentiation Syndrome: A potentially fatal complication (fever, dyspnea, fluid retention). Requires immediate treatment with high-dose corticosteroids.
  • ❤️ QT Prolongation: Irregular heartbeat.
  • 🤢 Gastrointestinal: Nausea, vomiting, diarrhea.
  • Hyperleukocytosis (rapid increase in white blood cells).
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Notice. The information on this page is for reference only and does not replace medical consultation. Always consult a healthcare professional and read the manufacturer's instructions before using any medicine. Self-medication may be dangerous. Information updated: 18.03.2026

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