Imbruvica 140 — Ibrutinib 140 mg (120 Capsules)

Imbruvica is used for the treatment of adult patients with the following blood disorders:

• 🔹 Chronic Lymphocytic Leukemia (CLL) / Small Lymphocytic Lymphoma (SLL): Including previously untreated patients and patients with relapse.
• 🔹 Mantle Cell Lymphoma (MCL): In patients who have received at least one prior therapy.
• 🔹 Waldenström's Macroglobulinemia: As monotherapy or in combination with rituximab.
• 🔹 Marginal Zone Lymphoma (MZL): For patients requiring systemic therapy.
• 🔹 Chronic Graft-Versus-Host Disease (cGVHD): After failure of one or more lines of systemic therapy.

Sales Form: 1 bottle contains 120 capsules of 140 mg.

⚠️ INSTRUCTIONS FOR USE:

• Dosage Regimen: Dosage depends on the type of disease. Usually, it is 420 mg (3 capsules) or 560 mg (4 capsules) once daily at the same time.
• Method: Capsules should be swallowed whole with a glass of water. Do not open, chew, or break the capsules.
• Important Restriction: During treatment, do not consume grapefruit, grapefruit juice, or Seville oranges, as they increase the drug level in the blood to dangerous values.
• Storage: Store at room temperature (up to 30°C) in a tightly closed bottle.

• ⛔ Hypersensitivity: Allergic reactions to ibrutinib.
• ⛔ Pregnancy and Planning: The drug is extremely dangerous for the fetus. The use of reliable contraception is mandatory for men and women during treatment and for 3 months after completion.
• ⛔ Lactation: Breastfeeding during therapy is strictly prohibited.
• ⛔ Infections and Surgery: Inform your doctor about planned surgical procedures (due to the risk of bleeding, the drug is discontinued 3–7 days before surgery).
• ⛔ Severe Hepatic Impairment: Requires special caution or exclusion of therapy.

Side effects requiring specialist attention may occur while taking Imbruvica:

• 🩸 Bleeding: Increased risk of bruising and nosebleeds.
• ❤️ Heart: Heart rhythm disturbances (atrial fibrillation, palpitations). ECG monitoring is required.
• 🤢 GI Tract: Diarrhea (most common), nausea, stomatitis.
• 🤒 Infections: Increased susceptibility to upper respiratory and urinary tract infections.
• 🦴 Musculoskeletal: Pain in muscles, joints, and bones.
• ⚠️ Important: If blood in the stool, pink urine, sudden dizziness, or severe headache occurs, seek medical attention immediately.