Lenvakast Lenvatinib 10 mg

Indicated for:

• Differentiated Thyroid Cancer (DTC): Radioiodine-refractory. Standard starting dose is 24 mg.
• Renal Cell Carcinoma (RCC): Advanced kidney cancer (in combination with Everolimus). Standard dose is 18 mg.
• Hepatocellular Carcinoma (HCC): First-line treatment for liver cancer (if weight ≥ 60 kg).

Strength: 10 mg per capsule.

Combination Examples:

• For 24 mg dose: Take two 10 mg capsules + one 4 mg capsule daily.
• For 20 mg dose: Take two 10 mg capsules daily.
• For 18 mg dose: Take one 10 mg capsule + two 4 mg capsules daily.

⚠️ Administration: Take once daily at the same time. Swallow whole with water. Do not crush, dissolve, or open.

• Severe uncontrolled Hypertension.
• Severe hepatic impairment.
• Active bleeding or history of gastrointestinal perforation/fistula.
• Pregnancy and breastfeeding.

Adverse reactions are common and may require dose interruption/reduction:

• Hypertension: High blood pressure is very frequent. Daily monitoring is advised.
• Proteinuria: Protein in urine.
• Fatigue, Diarrhea, Decreased Appetite.
• Palmar-plantar erythrodysesthesia syndrome (Hand-foot syndrome).