Sotoxen 320 — Sotorasib 320 mg Tablets

Prescribed by oncologists only after the KRAS G12C mutation is confirmed via testing:

• 🔹 Non-Small Cell Lung Cancer (NSCLC): Locally advanced or metastatic NSCLC in adult patients.
• 🔹 Indicated for patients who have received at least one prior systemic therapy (chemotherapy or immunotherapy).

Sales Unit: Bottle with 320 mg tablets.

⚠️ DOSING INSTRUCTIONS:

• Recommended Dose: 960 mg once daily. This equals taking 3 tablets of 320 mg at the same time.
• Administration: Swallow tablets whole with water. Can be taken with or without food, preferably at the same time each day.
• ⛔ Important: Do not chew, crush, or split the tablets.
• Missed Dose: If less than 6 hours have passed, take the dose. If more than 6 hours, skip the dose and resume the next day. Do not take 2 doses at once.

• ⛔ Interstitial Lung Disease (ILD): Or history of pneumonitis (drug can cause severe lung inflammation).
• Severe hepatic impairment (liver damage).
• Pregnancy and breastfeeding.
• Children (under 18 years of age).
• Hypersensitivity to Sotorasib.

Regular monitoring of liver function tests (ALT, AST) is mandatory. Potential side effects:

• 🩸 Hepatotoxicity: Elevated liver enzymes (common).
• 📉 Gastrointestinal: Diarrhea (very common), nausea, vomiting.
• 🦴 Musculoskeletal: Muscle or bone pain.
• ⚠️ Respiratory: Cough or shortness of breath (report new symptoms immediately due to risk of pneumonitis).