Tivoxen — Tivozanib 1.34 mg Capsules

Prescribed by oncologists for the treatment of adult patients with:

• 🔹 Relapsed or Refractory Advanced Renal Cell Carcinoma (RCC): Specifically following two or more prior systemic therapies.
• 🔹 Used as a third or fourth-line treatment option.

Sales Unit: 1 Bottle (21 Capsules of 1.34 mg).

⚠️ CYCLICAL DOSING SCHEDULE:

• Standard Regimen: Take 1 capsule (1.34 mg) once daily for 21 consecutive days.
• Rest Period: Followed by 7 days off treatment. The complete cycle is 28 days.
• Administration: Swallow the capsule whole with water. Can be taken with or without food.
• Missed Dose: If a dose is missed, do not take an extra dose. Take the next dose at your regular time the next day.

• ⛔ Pregnancy and Breastfeeding: Can cause fetal harm.
• Severe hepatic impairment.
• Children (under 18 years of age).
• Hypersensitivity to Tivozanib or tartrazine dye.
• Concomitant use of strong CYP3A4 inducers (may reduce efficacy).

Blood pressure monitoring is essential during therapy. Potential side effects:

• 🩸 Cardiovascular: Hypertension (high blood pressure) — very common.
• 📉 Gastrointestinal & General: Diarrhea, nausea, decreased appetite, fatigue.
• 🗣️ Dysphonia: Voice changes or hoarseness.
• 🧪 Hypothyroidism (thyroid dysfunction).