Zoldonat (Zoledronic Acid) 4 mg — 1 Vial

Indicated for:

• Bone Metastases: From solid tumors (breast cancer, prostate cancer, lung cancer, etc.) and Multiple Myeloma.
• Hypercalcemia of Malignancy (HCM): Life-threatening high calcium levels induced by cancer.

Form: Lyophilized powder (must be reconstituted and diluted).

Administration:

• 💉 Intravenous infusion over no less than 15 minutes. Administered every 3-4 weeks.
• Patient must be well-hydrated prior to infusion.

⚠️ CRITICAL WARNINGS:

• Dental Health: Complete all invasive dental work BEFORE starting therapy. Risk of Osteonecrosis of the Jaw (ONJ).
• Supplements: Patients usually take oral Calcium (500 mg) and Vitamin D (400 IU) daily, unless treating hypercalcemia.

• Severe renal impairment (Creatinine clearance < 30 mL/min).
• Pregnancy and breastfeeding.
• Hypocalcemia (low calcium levels).

"Post-Dose Syndrome":

Fever, chills, bone pain, and muscle aches are very common within the first 3 days of administration. This is temporary and can be managed with Paracetamol/Ibuprofen.

Serious Risks:

• Renal toxicity (Serum creatinine monitoring is mandatory before each dose).
• Osteonecrosis of the Jaw (ONJ).