Buy Anastrozole (Arimidex) online

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Known as original brand(s)

Arimidex

Buy Anastrozole (Arimidex) online with delivery. Browse medicines that contain Anastrozole, compare doses and prices.

Anastrozole is a highly selective third-generation non-steroidal aromatase inhibitor originally marketed under the brand name Arimidex. It is widely utilized in gynecologic oncology for the endocrine management of estrogen receptor-positive breast cancer in postmenopausal women, as well as in clinical endocrinology for estrogen suppression.

The mechanism of action of anastrozole involves reversible competitive inhibition of the aromatase enzyme (cytochrome P45019), which catalyzes the peripheral conversion of androgens (androstenedione and testosterone) into estrogens (estrone and estradiol). This results in a profound reduction of circulating estrogen levels (by 80–90%), effectively eliminating the hormonal stimulus for estrogen-dependent tumors.

Clinical administration of anastrozole reduces the risk of disease recurrence following surgery, slows the progression of advanced breast cancer, and helps regulate estrogen levels in specific therapeutic protocols.

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Anastrozole (Arimidex)

Indications

Anastrozole is indicated in clinical practice for the following conditions:

  • Adjuvant Breast Cancer Therapy: Treatment of postmenopausal women with estrogen receptor-positive early invasive breast cancer.
  • Advanced Breast Cancer: First-line treatment of postmenopausal women with advanced hormone-dependent breast cancer.
  • Second-Line Treatment: Management of advanced breast cancer in postmenopausal women with disease progression following prior tamoxifen therapy.

Dosage and administration

Anastrozole is intended for oral administration:

  • Recommended Dosage: The standard adult dose is 1 mg (one tablet) taken orally once daily.
  • Administration Method: Tablets should be swallowed whole with water, with or without food, preferably at the same time each day.
  • Duration of Treatment: For adjuvant therapy, the recommended total duration of treatment is 5 years or until tumor recurrence.
  • Monitoring: Postmenopausal status should be confirmed biochemically if menopausal status is uncertain prior to therapy initiation.

Anastrozole is contraindicated in the following cases:

  • Premenopausal Status: Active ovarian function / premenopausal women.
  • Pregnancy and Lactation: Pregnancy and breastfeeding periods due to potential teratogenic effects.
  • Severe Organ Impairment: Severe renal impairment (creatinine clearance less than 20 mL/min) or severe hepatic dysfunction.
  • Hypersensitivity: Known hypersensitivity to anastrozole or any core excipients.

Treatment with anastrozole may cause the following adverse reactions:

  • Vascular & General: Hot flashes, hyperhidrosis, fatigue, asthenia, and peripheral edema.
  • Musculoskeletal: Arthralgia, myalgia, back pain, and decreased bone mineral density leading to osteoporosis and fracture risk.
  • Nervous System: Headache, dizziness, insomnia, somnolence, anxiety, and depression.
  • Gastrointestinal: Nausea, vomiting, diarrhea, dry mouth, and transient liver enzyme elevations (ALT, AST).
  • Dermatologic: Rash, urticaria, hair thinning, or alopecia.
  • Cardiovascular: Hypertension and occasional ischemic events.

Frequently Asked Questions

Anastrozole is a potent and highly selective third-generation non-steroidal aromatase inhibitor that effectively blocks the aromatase enzyme responsible for converting androgens into estrogens in peripheral tissues. The reduction in circulating estrogen levels leads to a significant decrease in the stimulation of estrogen-sensitive cells, which is critical in the treatment of hormone-dependent tumors. The drug exhibits high specificity and does not significantly affect the synthesis of mineralocorticoids or glucocorticoids in the adrenal glands. The maximum concentration of the active substance in blood plasma is reached within two hours after oral administration, and steady-state concentration is established approximately after seven days of daily use. This pharmacodynamics ensures a stable and controlled anti-estrogenic effect throughout the course of therapy.
The main indication for prescribing Anastrozole is the treatment of advanced breast cancer in postmenopausal women with estrogen receptor-positive tumors. The drug is also widely used as adjuvant therapy for early-stage hormone-positive breast cancer following surgical intervention or radiation therapy. In addition, the medication is prescribed to patients with disease progression after standard tamoxifen therapy, provided their postmenopausal status is confirmed. In sports and bodybuilding, anastrozole is used by male athletes outside of official medical indications to control estrogen levels during the intake of aromatizing anabolic steroids to prevent gynecomastia. However, uncontrolled use of the drug by athletes can lead to a critical drop in estrogen and the development of associated metabolic disorders.
The standard recommended dosage of Anastrozole for adult female patients in oncological practice is one milligram once daily orally. The tablet should be swallowed whole with a sufficient amount of water, regardless of food intake, preferably at the same time of day. The course of treatment is usually long-term and may continue for five years as part of adjuvant therapy or until signs of disease progression appear. Dose adjustment for elderly patients or those with mild to moderate renal or hepatic impairment is not required. Independent modification of the dosage or premature discontinuation of the drug is strongly discouraged, as this may reduce treatment efficacy.
During the use of Anastrozole, hot flashes, vaginal dryness, hair thinning, arthralgia, and joint stiffness frequently occur. Long-term use of aromatase inhibitors can significantly reduce bone mineral density, increasing the risk of osteoporosis and fractures. To minimize bone risks, patients are recommended to undergo regular densitometry, take calcium supplements with vitamin D, and maintain physical activity. Cardiovascular side effects may include increased blood pressure and the development of coronary artery disease, which requires regular monitoring of blood parameters and lipid profile. If prominent adverse reactions appear, it is necessary to consult a healthcare provider immediately to adjust the therapy regimen.
Concurrent use of Anastrozole with estrogen-containing medications leads to mutual neutralization of the therapeutic effect and is strictly contraindicated. The simultaneous prescription of tamoxifen should also be avoided, as it can reduce the concentration of anastrozole in blood plasma and weaken its pharmacological action. The drug is not intended for use in premenopausal women, children, or pregnant and breastfeeding women due to the risk of teratogenic effects. Patients with impaired ability to drive vehicles and operate potentially dangerous machinery should exercise caution, as drowsiness and asthenia are sometimes observed during intake. A comprehensive medical evaluation is mandatory prior to starting treatment to rule out contraindications and assess the overall health status.

Medicines containing Anastrozole

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Anastronat
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Natco

Anastronat

Anastrozole
1 mg 30 tablets
1162₴ 1296₴
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