Buy Testosterone Undecanoate (Andriol) online

Price: 1,296 UAH

Known as original brand(s)

Andriol, Nebido

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Testosterone undecanoate is a long-acting ester of the natural male androgen testosterone, originally marketed under the brand name Nebido (also known under the brand name Aveed in the US, and Andriol/Jatenzo for oral formulations). It is widely used in urology and endocrinology for testosterone replacement therapy (TRT) in hypogonadal men.

The mechanism of action involves the systemic release of active testosterone following the cleavage of the ester side chain. Testosterone binds to androgen receptors to promote the development and maintenance of male sex organs, secondary sex characteristics, muscle mass, bone density, and stimulation of erythropoiesis.

Clinical administration of testosterone undecanoate restores serum testosterone levels to physiological ranges, improving libido, erectile function, mood, body composition, and overall quality of life in men with androgen deficiency.

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Testosterone Undecanoate (Andriol)

Indications

Testosterone undecanoate is indicated in endocrinology and andrology for the following conditions:

  • Testosterone Replacement Therapy: Replacement therapy for primary and secondary hypogonadism in males when testosterone deficiency has been confirmed by clinical features and biochemical tests.
  • Symptomatic Relief: Management of symptoms associated with male hypogonadism (e.g., impotence, decreased sex drive, fatigue, depressive moods, and bone loss).

Dosage and administration

Testosterone undecanoate comes in two forms. The regimen is chosen by a doctor after a blood testosterone test.

Oral capsules (40 mg — Andriol Testocaps and generics):

  • Starting dose: 120–160 mg a day (3–4 capsules) for 2–3 weeks.
  • Maintenance dose: 40–120 mg a day (1–3 capsules).
  • How to take: split the daily dose into two intakes, morning and evening, with a meal containing fat (without fat the drug is barely absorbed). Swallow the capsules whole, without chewing.

Solution for injection (1000 mg / 4 mL — Nebido):

Testosterone undecanoate oily solution (1000 mg / 4 mL) is administered strictly via deep intramuscular injection:

  • Recommended Dosage: One vial/ampoule (1000 mg testosterone undecanoate) is injected intramuscularly every 10 to 14 weeks.
  • Injection Interval: To achieve rapid steady-state testosterone levels, the second injection may be administered 6 weeks after the first dose, followed by the standard 10 to 14-week interval.
  • Administration Technique: Injections must be administered very slowly (over 2 minutes) deep into the gluteal muscle, strictly avoiding intravascular injection.
  • Monitoring: Regular monitoring of serum testosterone, hematocrit, hemoglobin, lipid profile, and prostate health (PSA and digital rectal examination) is required before and during treatment.

Testosterone undecanoate is contraindicated in the following cases:

  • Oncological Conditions: Androgen-dependent carcinoma of the prostate or male mammary gland (or suspicion thereof).
  • Hepatic Tumors: Past or present liver tumors.
  • Cardiovascular Conditions: Severe heart failure, uncontrolled hypertension.
  • Hypercalcemia: Hypercalcemia accompanying malignant tumors.
  • Gender and Age: Strictly contraindicated in women, children, and adolescents under 18 years of age.
  • Hypersensitivity: Known hypersensitivity to testosterone undecanoate or to castor oil.

Testosterone undecanoate therapy may be associated with the following adverse reactions:

  • Hematologic System: Erythrocytosis (increased hemoglobin/hematocrit), polycythemia.
  • Prostate Health: Increased prostate-specific antigen (PSA), benign prostatic hyperplasia.
  • Injection Site Reactions: Pain, discomfort, induration at the injection site; rare pulmonary oily microembolism (cough, dyspnea immediately post-injection).
  • Metabolic & Endocrine: Weight gain, fluid retention, gynecomastia, dyslipidemia.
  • Dermatologic: Acne, alopecia, pruritus.
  • Reproductive System: Priapism, oligospermia, decreased ejaculatory volume.

Frequently Asked Questions

Testosterone undecanoate is an esterified derivative of endogenous testosterone, the primary male androgen. Once administered, the ester is cleaved to release natural testosterone, which is essential for the development and maintenance of male reproductive tissues, secondary sexual characteristics (such as facial hair growth and deep voice), stimulation of erythropoiesis, maintenance of muscle mass, bone mineral density, libido, and energy levels. The undecanoate ester allows for a sustained, steady release of testosterone into the bloodstream, minimizing sharp peaks and fluctuations in hormone levels.
The principal clinical indication for testosterone undecanoate is testosterone replacement therapy (TRT) in adult men diagnosed with primary or secondary hypogonadism. The medication is indicated when serum testosterone deficiency is verified by both clinical symptoms—such as decreased libido, erectile dysfunction, persistent fatigue, mood changes, decreased muscle mass, and osteopenia—and confirmed baseline laboratory blood assays.
Testosterone undecanoate is available in two main pharmaceutical formulations: Oral capsules: Administered daily with meals containing dietary fat, as absorption occurs via the intestinal lymphatic system, bypassing first-pass hepatic metabolism and reducing liver toxicity. Intramuscular depot injections: An oil-based formulation injected deeply into the gluteal muscle over long intervals (typically one injection every 10 to 14 weeks following loading doses). The injectable form yields a sustained, physiologically steady hormone profile.
Testosterone undecanoate is strictly contraindicated in men with known or suspected prostate carcinoma or breast cancer. Prior to starting treatment, all male patients over 40 years of age must undergo a digital rectal examination and a prostate-specific antigen (PSA) blood test to rule out pre-existing malignancies. Routine, ongoing monitoring of PSA levels and digital exams during therapy is mandatory, as exogenous androgens can accelerate the growth of undiagnosed androgen-dependent prostatic lesions.
Because exogenous testosterone stimulates erythropoiesis, patients face an elevated risk of secondary erythrocytosis, which increases blood viscosity and thrombotic risk. Patients must undergo routine complete blood counts to monitor hematocrit and hemoglobin levels; if hematocrit exceeds 54%, therapy should be temporarily paused. Additionally, serum total testosterone levels must be checked to calibrate optimal dosing, alongside periodic lipid panel assessments (cholesterol) and liver function testing. Каким следующим действующим веществом или препаратом мы займемся для проекта Indiafarm?

Medicines containing Testosterone Undecanoate

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Testoheal
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Healing Pharma

Testoheal

Testosterone Undecanoate
40 mg 30 capsules
1296₴ 1520₴
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